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Tea intake and lung diseases: a Mendelian randomization study.

Zhengyan Wu1, Min Jiao2, Chenying Shu3

  • 1Department of Health Management Center, The First Affiliated Hospital of Soochow University, Suzhou, China.

Frontiers in Immunology
|February 20, 2024
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Summary
This summary is machine-generated.

Standard tea intake, particularly black tea, is causally linked to an increased risk of lung squamous cell cancer (LSCC). This association may involve B lymphocyte activation, warranting caution for black tea consumers.

Keywords:
Mendelian randomizationblack tea intakecausal relationshipgreen tea intakelung diseasessquamous cell lung cancerstandard tea intake

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Area of Science:

  • Genetics
  • Epidemiology
  • Oncology

Background:

  • Inconsistent findings exist regarding tea consumption and lung disease risk.
  • The precise impact of tea intake on the respiratory system requires further clarification.

Purpose of the Study:

  • To investigate the causal associations between five tea intake phenotypes and 15 respiratory outcomes using a two-sample Mendelian randomization approach.
  • To explore potential underlying mechanisms through pathway enrichment analysis.

Main Methods:

  • Utilized open Genome-wide association study (GWAS) data for a two-sample Mendelian randomization (MR) study.
  • Employed inverse variance weighted (IVW) method for primary analysis and complementary methods for sensitivity analysis.
  • Conducted KEGG and GO enrichment analysis to identify biological pathways.

Main Results:

  • Identified a causal effect of standard tea intake on increased lung squamous cell cancer (LSCC) risk (OR = 1.004; P = 0.00299).
  • The association remained robust after multivariable MR adjustment for smoking, education, and television viewing.
  • No significant causalities were found for other tea types or respiratory outcomes.
  • Pathway analysis suggested B lymphocyte proliferation and activation as potential mediators.

Conclusions:

  • Provided causal evidence for an independent effect of standard tea intake (black tea) on LSCC risk.
  • The observed association may be mediated by B lymphocytes.
  • Individuals who prefer black tea should be aware of a potentially elevated LSCC risk.