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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

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Disentangling differing relationships between internalizing disorders and alcohol use.

Maizy S Brasher^1,2, Andrew D Grotzinger^1,3, Naomi P Friedman^1,3

¹Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, USA.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics

|February 20, 2024

Summary

This summary is machine-generated.

Shared genetic factors influence both internalizing disorders and alcohol use. Accounting for externalizing traits reveals the complex interplay, highlighting the need to study genetic heterogeneity within disorders.

Keywords:

alcohol use comorbity genetic correlation genomic SEM internalizing

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Area of Science:

Psychiatric Genetics
Behavioral Science
Global Health

Background:

Internalizing disorders and alcohol use present significant global health challenges.
Previous research indicates shared genetic variations and phenotypic comorbidity between these conditions.
Understanding the genetic underpinnings is crucial for addressing comorbidity.

Purpose of the Study:

To investigate the shared genetics of internalizing, externalizing, and alcohol use traits.
To explore how specific internalizing symptom domains mediate relationships with alcohol use.
To examine genetic correlations across different ancestry groups.

Main Methods:

Genomic structural equation modeling was employed.
Analysis included internalizing, externalizing, and alcohol use traits.
Genetic correlations were examined in Finnish and East Asian populations.

Main Results:

The genetic influence of internalizing traits on alcohol use decreased when externalizing psychopathology was controlled.
Individual internalizing domains showed contrasting effects on alcohol consumption frequency.
This suggests common genetic factors underlie multiple psychiatric disorders and their comorbidity with alcohol use.

Conclusions:

Common genetic factors play a significant role in the comorbidity of internalizing disorders and alcohol use.
Specific internalizing domains have differential genetic influences on alcohol consumption patterns.
Future research should consider both broad shared psychopathology and fine-scale genetic heterogeneity.