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Related Concept Videos

Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Association Between Metabolic Syndrome And The Risk Of Colorectal Cancer: A Prospective Study In China

Association between metabolic syndrome and the risk of colorectal cancer: a prospective study in China

Zhongge Wang1, Ruirui Chen, Lizhen Zhang

  • 1Department of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, 199 Donggang West Street, Lanzhou, Gansu, China.

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
|February 20, 2024

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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
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Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

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View abstract on PubMed

Summary
This summary is machine-generated.

Metabolic syndrome (MetS) increases colorectal cancer (CRC) risk, particularly in males with hyperglycemia. This association was also significant for smokers and drinkers, highlighting MetS as a key risk factor for CRC development.

Area of Science:

  • Epidemiology
  • Metabolic Health
  • Oncology

Background:

  • Metabolic syndrome (MetS) is a cluster of conditions that increase the risk of heart disease, stroke, and type 2 diabetes.
  • Colorectal cancer (CRC) is a significant global health concern with multifactorial etiology.
  • Understanding the interplay between metabolic health and cancer development is crucial for preventive strategies.

Purpose of the Study:

  • To investigate the association between metabolic syndrome (MetS) and its individual components with the incidence of colorectal cancer (CRC).
  • To explore potential dose-response relationships and identify specific risk factors within MetS contributing to CRC development.
  • To analyze these associations in a large prospective cohort from Jinchang, China.

Main Methods:

  • A prospective cohort study involving 43,516 individuals from the Jinchang Cohort (2011-2020).

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  • Cox proportional hazard models were used to calculate Hazard Ratios (HRs) and 95% Confidence Intervals (CIs) for CRC risk.
  • Restricted cubic spline models assessed dose-response relationships, particularly for fasting plasma glucose (FPG).

    • Main Results:

    • Metabolic syndrome (MetS) was significantly associated with an increased risk of CRC (HR: 1.64).
    • Hyperglycemia was a key driver, showing a strong association with incident CRC (HR: 1.70).
    • The association was more pronounced in males and in individuals who smoke or consume alcohol. A linear dose-response relationship was observed between FPG and CRC risk in males.

    Conclusions:

    • Metabolic syndrome (MetS) is a significant risk factor for colorectal cancer (CRC) incidence.
    • Hyperglycemia plays a crucial role in the MetS-CRC link, especially in males.
    • While MetS overall increases CRC risk, individual components other than hyperglycemia did not show a significant association in this cohort.