Related Experiment Video

Updated: Jul 2, 2025

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
10:49

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

Published on: September 20, 2016

12.6K

Correction: Detecting molecular interactions in live-cell single-molecule imaging with proximity-assisted

Thomas G W Graham, John Joseph Ferrie, Gina M Dailey

    Elife
    |February 20, 2024
    PubMed
    Abstract

    No abstract available in PubMed .

    Keywords:
    cell biologyhumanmolecular biophysicsstructural biology

    More Related Videos

    Visualizing Protein-DNA Interactions in Live Bacterial Cells Using Photoactivated Single-molecule Tracking
    16:21

    Visualizing Protein-DNA Interactions in Live Bacterial Cells Using Photoactivated Single-molecule Tracking

    Published on: March 10, 2014

    17.8K
    Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
    14:43

    Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

    Published on: August 27, 2014

    11.6K

    Related Experiment Videos

    Last Updated: Jul 2, 2025

    Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
    10:49

    Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

    Published on: September 20, 2016

    12.6K
    Visualizing Protein-DNA Interactions in Live Bacterial Cells Using Photoactivated Single-molecule Tracking
    16:21

    Visualizing Protein-DNA Interactions in Live Bacterial Cells Using Photoactivated Single-molecule Tracking

    Published on: March 10, 2014

    17.8K
    Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
    14:43

    Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

    Published on: August 27, 2014

    11.6K

    Related Concept Videos

    Protein Dynamics in Living Cells01:19

    Protein Dynamics in Living Cells

    2.1K
    Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
    Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...
    2.1K
    Labeling DNA Probes03:31

    Labeling DNA Probes

    8.2K
    DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
    Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
    8.2K

    Articles linked to this work by shared authors, journal, and citation graph.

    Exchange dynamics and kinetic control of gene regulation complexes.

    Nature reviews. Molecular cell biology·2026

    Elevated MyoD1 levels expand genome-wide binding and the repertoire of regulated genes.

    Proceedings of the National Academy of Sciences of the United States of America·2026

    Unstructured transcription factor interactions enable emergent specificity.

    Science (New York, N.Y.)·2026

    Spatial microenvironments tune immune response dynamics in the Drosophila larval fat body.

    PLoS genetics·2026

    FOXA1 mutations co-opt nascent transcription factor networks in partnership with androgen receptor to enhance prostate tumorigenicity.

    Cell reports·2026

    Short activation domains control chromatin association of transcription factors.

    eLife·2026

    Designing optimal perturbation inputs for system identification in neuroscience.

    eLife·2026

    Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly.

    eLife·2026

    Gluconeogenic compensation renders glycogen phosphorylase non-essential as an insecticidal target in Plutella xylostella.

    eLife·2026

    Reduced dorsal CA1 activity limits retention of the temporal component of declarative memory in the Cntnap2 knockout mouse model of autism.

    eLife·2026

    A framework for analyzing global Caenorhabditis elegans neural activity.

    eLife·2026

    Allosteric disulfide control of ligand binding and endocytosis of KIR2DL4, the natural killer cell receptor for HLA-G.

    eLife·2026

    Transcription start site aware catalogue of microRNA encoded peptides in tomato (Solanum lycopersicum).

    Discover plants·2026

    Application of Panax notoginseng Saponins in Skin Wound Repair: Mechanisms and Research Progress.

    Journal of cellular and molecular medicine·2026

    PKM2 AP: a micropeptide inhibits vascular calcification via molecular glue-mediated ubiquitination of PKM2.

    Nature communications·2026

    Protein interactions with small molecules, peptides and proteins share residue cluster classes.

    Journal of molecular graphics & modelling·2026

    Evolution, structural diversity and functional plasticity of plant derived multifunctional proteases and α-amylases inhibitors.

    Plant molecular biology·2026

    Positive allosteric modulators of AMPA receptors: advances and emerging trends.

    Expert opinion on therapeutic patents·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies
    Jove
    Visualize
    Contact Us