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Evaluation of quality of life in children with precocious puberty

İlkay N Yılmazer1, Sema Nilay Abseyi2, Gizem Şenyazar2

  • 1Department of Pediatric, Ankara University Faculty of Medicine, Ankara, Turkey.

Clinical Endocrinology
|February 20, 2024
PubMed

Insights

Children with central precocious puberty (CPP) receiving treatment and those with premature thelarche (PT) without treatment showed no significant difference in quality of life compared to healthy peers. This suggests treatment for CPP does not negatively impact a child's quality of life.

Area of Science:

  • Pediatric Endocrinology
  • Quality of Life Research
  • Child Psychology

Background:

  • Central precocious puberty (CPP) and premature thelarche (PT) are conditions affecting childhood development.
  • The impact of treatment on the quality of life (QoL) for children with CPP is not fully understood.
  • Sociodemographic factors and treatment status may influence QoL in these pediatric populations.

Purpose of the Study:

  • To investigate and compare the quality of life (QoL) in children with central precocious puberty (CPP) undergoing treatment.
  • To assess and compare the QoL in children with premature thelarche (PT) managed without treatment.
  • To compare the QoL of these patient groups with that of healthy children.

Main Methods:

  • A case-control study design was employed.
  • 193 children participated: 59 with CPP, 53 with PT, and 81 healthy controls.
  • The Pediatric Quality of Life Inventory (PedsQL) and a sociodemographic questionnaire were utilized.

Main Results:

  • No statistically significant differences in PedsQL scores (total, psychosocial, physical) were found between CPP, PT, and control groups (p > .05).
  • Parental assessment scores for QoL were also similar across the three groups.
  • Sociodemographic data did not differ significantly among the CPP, PT, and control groups.

Conclusions:

  • Quality of life in children with CPP receiving treatment is comparable to those with PT and healthy children.
  • Treatment initiation for CPP did not demonstrate a negative impact on the assessed quality of life.
  • This study highlights that QoL is not significantly affected by CPP treatment or PT, contrary to some previous assumptions.
Abstract

Keywords:
Pediatric Quality of Life InventoryPedsQLprecocious pubertypubertyquality of life

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