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Heart failure during acute coronary syndrome and the long-term cancer risk: the ABC-9 Study on heart disease
Heba T Mahmoud1,2, Giuseppe Berton1, Rocco Cordiano1,3
1The ABC Study on Heart Disease Foundation-ONLUS, Conegliano, Italy.
Heart failure (HF) during acute coronary syndrome (ACS) hospitalization was linked to a lower long-term cancer risk in a 24-year study. This inverse association suggests a complex relationship between cardiovascular health and cancer development.
Area of Science:
- Cardiology
- Oncology
- Epidemiology
Background:
- Community studies suggest a higher cancer risk in heart failure (HF) patients.
- The impact of HF during acute coronary syndrome (ACS) hospitalization on long-term cancer risk requires investigation.
Purpose of the Study:
- To investigate the impact of HF during ACS hospitalization on long-term cancer risk.
- To analyze the association between HF, left ventricular ejection fraction (LVEF), and cancer incidence and mortality.
Main Methods:
- Prospective follow-up of 572 ACS patients for 24 years.
- Cox regression and competing risk regression analyses were used.
- Propensity score matching was employed to control for confounding factors.
Main Results:
- No difference in cancer onset or death rates was observed based on HF status.
- Competing risk analysis showed an inverse association between HF and cancer onset (SHR: 0.47).
- Left ventricular ejection fraction (LVEF) was associated with increased cancer risk (SHR: 1.02).
Conclusions:
- An inverse association between baseline HF and long-term cancer risk was observed in ACS patients.
- Age interacted with HF and LVEF, influencing cancer risk.
- Further research is needed to elucidate the complex interplay between cardiovascular conditions and cancer.
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