Related Experiment Video

Updated: Jul 2, 2025

Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

27.6K

Clinical characteristics of children with asthma exacerbations: a cross-sectional descriptive study

Ezgi Cay1, Veysel Karakulak2, Ahmet Sezer2

  • 1Department of Pediatrics, Faculty of Medicine, Balcali Hospital, Cukurova University, Adana, Turkey.

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
|February 20, 2024
PubMed

Insights

Asthma exacerbations in children are more severe with bacterial infections, atopic disease, and poor treatment adherence. These factors, along with Alternaria exposure, predict severity in pediatric asthma patients.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Clinical Research

Background:

  • Asthma exacerbations in children are a significant cause of hospital admissions.
  • Identifying factors predicting exacerbation severity is crucial for effective management.
  • Aeroallergen prevalence in southern Turkey necessitates understanding their role in pediatric asthma.

Purpose of the Study:

  • To determine clinical characteristics of pediatric asthma exacerbations in southern Turkey.
  • To investigate the impact of these characteristics on exacerbation severity.
  • To identify predictors of severe asthma exacerbations in children.

Main Methods:

  • Cross-sectional descriptive study analyzing retrospectively collected data.
  • Included 106 children with asthma and no comorbidities.
  • Compared clinical and laboratory parameters between mild/moderate and severe exacerbations.

Main Results:

  • 18.8% of children experienced severe asthma exacerbations.
  • Severe exacerbations were linked to atopic disease, Alternaria positivity, frequent prior exacerbations, Streptococcus pneumoniae infection, and poor treatment adherence.
  • Patients with severe exacerbations showed lower Peak Expiratory Flow (PEF), Forced Expiratory Volume in 1 second (FEV1), and FEV1/Forced Vital Capacity (FVC) values.

Conclusions:

  • Bacterial infections, atopic disease, and Alternaria exposure are associated with severe pediatric asthma.
  • Low spirometric measures and a history of frequent exacerbations predict severity.
  • Treatment adherence is a critical factor in managing pediatric asthma exacerbations.
Abstract

Keywords:
Asthmaasthma exacerbationsasthma in children

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.4K
A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

22.5K

Related Concept Videos

Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.5K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
398
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.5K