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Updated: Jul 2, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
Melanocortin-1 receptor (MC1R): a review for dermatologists
Stefania Guida1,2, Susana Puig3, Chiara DI Resta4,5
1Dermatology Clinic, IRCCS San Raffaele Hospital, Milan, Italy - guida.stefania@hsr.it.
Abstract:
Melanocortin-1 receptor (MC1R) and its variants have a pivotal role in melanin synthesis. However, MC1R has been associated to non-pigmentary pathways related to DNA-repair activities and inflammation. The aim of this review is to provide an up-to-date overview about the role of MC1R in the skin. Specifically, after summarizing the current knowledge about MC1R structure and polymorphisms, we report data concerning the correlation between MC1R, phenotypic traits, skin aging, other diseases and skin cancers and their risk assessment through genetic testing.
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