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Related Concept Videos

Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

127
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
137
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
119
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

163
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

141
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Updated: Jul 2, 2025

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
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Antibiotics for inflammatory bowel disease: Current status.

Daya K Jha1, Shubhra Mishra2, Usha Dutta3

  • 1Indian Navy, Visakhapatnam, 530 014, India.

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|February 20, 2024
PubMed
Summary

Antibiotics offer clear benefits for specific inflammatory bowel disease (IBD) complications like fistulas and abscesses, but routine use for all flares lacks evidence. Careful consideration of targeted antibiotic therapy is crucial for IBD management.

Keywords:
Escherichia coliAntibioticsAntimicrobial agentsAntitubercular therapyCrohn’s diseaseGastrointestinal tuberculosisUlcerative colitis

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Area of Science:

  • Gastroenterology
  • Microbiology
  • Clinical Medicine

Background:

  • The role of antibiotics in inflammatory bowel disease (IBD) management remains unclear despite extensive literature.
  • Infectious agents are implicated in Crohn's disease pathogenesis and may trigger ulcerative colitis flares.

Purpose of the Study:

  • To review the existing literature on antibiotic use in IBD.
  • To provide clinical guidance on appropriate antibiotic application in various IBD scenarios.

Main Methods:

  • Systematic review of published literature on antibiotic use in IBD.
  • Assessment of evidence for antibiotic efficacy in specific IBD conditions and flares.

Main Results:

  • Antibiotics are beneficial for perianal fistulas, intra-abdominal abscesses, acute pouchitis, and infection-related flares in IBD.
  • Routine antibiotic use for all IBD flares lacks evidence; intravenous antibiotics show limited benefit in ulcerative colitis.
  • Targeted antibiotic regimens show mixed results, with some benefit for Fusobacterium varium in ulcerative colitis and limited symptomatic improvement without durable benefit for antimycobacterial therapy in Crohn's disease.

Conclusions:

  • Antibiotic use in IBD should be targeted to specific indications rather than routine application for all flares.
  • Careful consideration and judicious use of antibiotics are essential for effective IBD management.
  • Further research is needed to clarify the role of specific antibiotic regimens in IBD treatment.