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The Global Epidemic of Metabolic Fatty Liver Disease

Ethan C Z Lee1, Vickram V Anand1, Alex C Razavi2

  • 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Current Cardiology Reports
|February 20, 2024
PubMed
Abstract

Insights

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health concern, strongly linked to cardiovascular disease (CVD). The shift from NAFLD to MASLD highlights the importance of metabolic factors and necessitates further research into effective treatments.

Area of Science:

  • Hepatology and Gastroenterology
  • Cardiology
  • Metabolic Diseases

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly NAFLD, is increasingly prevalent.
  • Cardiometabolic risk factors are central to MASLD pathophysiology.
  • MASLD is a significant risk factor for cardiovascular disease (CVD).

Purpose of the Study:

  • To review the epidemiology of MASLD.
  • To examine the association between MASLD and CVD outcomes.
  • To evaluate the impact of the nomenclature change from NAFLD to MASLD.

Main Methods:

  • Literature review of epidemiological studies.
  • Analysis of research on MASLD and CVD correlations.
  • Evaluation of diagnostic criteria updates.

Main Results:

  • The MASLD nomenclature reduces stigma and emphasizes metabolic factors.
  • MASLD incidence and prevalence are rising due to increasing cardiometabolic risk.
  • MASLD is a potent risk factor for CVD, requiring a multidisciplinary approach.

Conclusions:

  • The global epidemic of MASLD is expected to grow.
  • Further research is needed to validate findings from previous NAFLD studies under the new MASLD criteria.
  • Urgent development of therapeutic strategies is required to combat the rising trend of MASLD.
Keywords:
Cardiometabolic diseaseCardiovascular diseaseMetabolic-associated fatty liver diseaseMetabolic dysfunction-associated steatotic liver diseaseNon-alcoholic fatty liver disease

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