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Early Life Androgen Administration Attenuates Aging Related Declines in Muscle Protein Synthesis

David D Church1, Amit Zamir2, Guillermo Escalante3

  • 1Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging & Longevity, University of Arkansas for Medical Sciences, Little Rock, AR.

Medicine and Science in Sports and Exercise
|February 20, 2024
PubMed
Abstract

Insights

Nandrolone decanoate (ND) increased kidney and muscle fractional synthetic rates (FSR) in mice. Long-term use of ND appeared to maintain elevated muscle FSR during aging.

Area of Science:

  • Physiology
  • Pharmacology
  • Biochemistry

Background:

  • Anabolic-androgenic steroids (AAS) like nandrolone decanoate (ND) are performance-enhancing drugs.
  • Understanding the long-term effects of AAS on tissue synthesis is crucial for health and performance research.

Purpose of the Study:

  • To investigate the acute and long-term impacts of nandrolone decanoate (ND) on fractional synthetic rates (FSR) in various tissues.
  • To determine if ND administration influences tissue FSR during aging.

Main Methods:

  • Male C57BL/6 mice were administered ND or a sham treatment for 6 weeks, starting at 7 months of age.
  • Tissue samples (kidney, liver, heart, gastrocnemius, soleus) were analyzed for FSR using deuterated water labeling and liquid chromatography-tandem mass spectrometry.
  • Animals were assessed at 1 week post-cessation and at 16 months of age to evaluate acute and long-term effects.

Main Results:

  • Kidney FSR was elevated in ND-treated mice compared to sham and higher in younger compared to older mice.
  • Liver and heart FSR were significantly higher in younger mice than in older mice, with no difference between ND and sham groups.
  • Gastrocnemius FSR was higher in younger than older mice and also greater in ND-treated mice compared to sham.
  • Soleus FSR was higher in younger mice, and old animals receiving ND showed elevated FSR in gastrocnemius and soleus muscles.

Conclusions:

  • Nandrolone decanoate (ND) administration resulted in increased kidney and muscle fractional synthetic rates.
  • Long-term ND use in young adult mice appeared to sustain elevated muscle FSR during the aging process.

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