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Published on: January 5, 2018
CRISPR/Cas9: an overview of recent developments and applications in cancer research
Nandibala Devi Shamjetsabam1, Rashmi Rana1, Priyanka Malik2
1Department of Biotechnology and Research, Sir Ganga Ram Hospital New Delhi.
Abstract:
Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 (Cas9) has risen as a potent gene editing method with vast potential across numerous domains, including its application in cancer research and therapy. This review article provides an extensive overview of the research that has been done so far on CRISPR-Cas9 with an emphasis on how it could be utilized in the treatment of cancer. The authors go into the underlying ideas behind CRISPR-Cas9, its mechanisms of action, and its application for the study of cancer biology. Furthermore, the authors investigate the various uses of CRISPR-Cas9 in cancer research, spanning from the discovery of genes and the disease to the creation of novel therapeutic approaches. The authors additionally discuss the challenges and limitations posed by CRISPR-Cas9 technology and offer insights into the potential applications and future directions of this cutting-edge field of research. The article intends to consolidate the present understanding and stimulate more research into CRISPR-Cas9's promise as a game-changing tool for cancer research and therapy.
Insights
Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated protein 9 (Cas9) gene editing offers powerful tools for cancer research and therapy. This review explores CRISPR-Cas9
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- CRISPR-Cas9 is a revolutionary gene-editing technology.
- Its potential applications in cancer research and treatment are significant.
- Understanding CRISPR-Cas9 mechanisms is crucial for advancing cancer therapy.
Purpose of the Study:
- To provide a comprehensive overview of CRISPR-Cas9 research in cancer.
- To highlight the utility of CRISPR-Cas9 in cancer biology studies and therapeutic development.
- To discuss current challenges and future prospects of CRISPR-Cas9 in oncology.
Main Methods:
- Review of existing scientific literature on CRISPR-Cas9 and cancer.
- Analysis of CRISPR-Cas9 mechanisms and their application in cancer research.
- Exploration of gene discovery, disease modeling, and therapeutic strategies using CRISPR-Cas9.
Main Results:
- CRISPR-Cas9 facilitates gene discovery and understanding of cancer biology.
- It enables the development of novel cancer treatment strategies.
- The technology presents both opportunities and challenges in clinical translation.
Conclusions:
- CRISPR-Cas9 is a transformative tool with immense potential for cancer research and therapy.
- Further research is needed to overcome limitations and fully realize its therapeutic promise.
- This review consolidates current knowledge and encourages future investigations.
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