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Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

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Related Experiment Video

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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
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Meta-Analysis of Normal Reference Values for Right and Left Ventricular Quantification by Cardiovascular Magnetic

Yang Zhan1,2, Matthias G Friedrich3,4, Nandini Dendukuri5

  • 1Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC (Y.Z., J.A.).

Circulation. Cardiovascular Imaging
|February 20, 2024
PubMed
Summary

This meta-analysis provides updated cardiovascular magnetic resonance (CMR) reference values for left ventricular (LV) and right ventricular (RV) parameters in healthy adults. These new ranges account for diverse populations and common tracing techniques, improving diagnostic accuracy.

Keywords:
heart ventriclesmagnetic resonance imagingmeta-analysisreference values

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Biostatistics

Background:

  • Cardiovascular magnetic resonance (CMR) is crucial for diagnosing left ventricular (LV) and right ventricular (RV) pathologies.
  • Existing CMR reference values are limited by small sample sizes, lack of diversity, and inconsistent tracing methods for papillary muscles and trabeculations.
  • This study addresses these limitations by performing a comprehensive meta-analysis of normal CMR reference values.

Approach:

  • A systematic review and meta-analysis of published and unpublished data from 254 studies involving 12,812 healthy adults was conducted.
  • A Bayesian hierarchical meta-analysis model was employed to derive pooled reference values, accounting for differences between tracing techniques (LV volume vs. mass).
  • Data from 52 studies were meta-analyzed, utilizing steady-state free-precession short-axis stacks at 1.5T or 3T.

Key Points:

  • Pooled normative reference ranges for LV and RV ejection fraction, end-diastolic volume index, end-systolic volume index, and mass index were established for men and women.
  • Specific ranges were provided for LV parameters based on tracing techniques (volume vs. mass).
  • For example, LV ejection fraction in men ranged from 52% to 73% (volume) and 57% to 74% (mass).

Conclusions:

  • This Bayesian hierarchical meta-analysis establishes comprehensive, multinational normative reference values for CMR parameters of LV and RV size, systolic function, and mass.
  • The derived values encompass both commonly used tracing techniques, enhancing the reliability of CMR diagnostics.
  • These updated reference values are essential for accurate diagnosis and management of cardiovascular diseases across diverse patient populations.