Related Experiment Video
Updated: Jul 21, 2026
05:48
Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
Published on: March 18, 2014
9.8K
Comparison of Different Acellular Dermal Matrix in Breast Reconstruction: A Skin-to-Skin Study
Aesthetic Surgery Journal
|February 20, 2024
Summary
This study compared AlloDerm and DermACELL in breast reconstruction, finding both effective. DermACELL showed fewer seromas and better incorporation than AlloDerm.
Area of Science:
- Plastic Surgery
- Biomaterials Science
Background:
- Acellular dermal matrix (ADM) is widely used in prepectoral breast reconstruction.
- Enhancing outcomes in breast reconstruction is a key goal.
Purpose of the Study:
- To compare the postoperative outcomes of two ADM products: AlloDerm SELECT Ready To Use and DermACELL.
- To identify differences in complication rates and incorporation between the two ADM products.
Main Methods:
- Prospective, patient-blinded, comparative study.
- 55 patients undergoing bilateral mastectomies with ADM were their own controls.
- Outcomes assessed included drain removal time, infection, seroma, and incorporation rates.
Main Results:
- No significant differences in drain removal time or output.
- AlloDerm had a higher seroma rate (30.91%) compared to DermACELL (14.55%).
- DermACELL demonstrated significantly higher incorporation rates (99.8%) than AlloDerm (93.4%).
Conclusions:
- Both AlloDerm and DermACELL achieve high success rates in breast reconstruction.
- DermACELL may offer advantages due to lower seroma incidence and superior incorporation.
- Further research may clarify long-term differences in ADM performance.
Related Concept Videos
01:12Renewal of Skin Epidermal Stem Cells
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
01:11Papillary Dermis
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
01:27The Skin Microbiota
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...