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Related Concept Videos

Hypodermis01:02

Hypodermis

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The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Sympathetic Signaling01:32

Sympathetic Signaling

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Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
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Sensory Functions of the Skin01:16

Sensory Functions of the Skin

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Regulation of Food Intake01:30

Regulation of Food Intake

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Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
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Adrenergic Receptors (Adrenoceptors): Classification01:27

Adrenergic Receptors (Adrenoceptors): Classification

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Adrenergic receptors, or adrenoceptors, respond to the autonomic neurotransmitter noradrenaline and other endogenous catecholamine agonists. They are classified into two main families, α and β, based on their pharmacological response and are further subdivided depending on their location, elicited response, and affinity to specific agonists or antagonists.
α-Adrenoceptors
α-Adrenoceptors are classified into two main subtypes: α1 and α2. The α1 adrenoceptors,...
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Related Experiment Video

Updated: Jul 2, 2025

Co-staining Blood Vessels and Nerve Fibers in Adipose Tissue
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Co-staining Blood Vessels and Nerve Fibers in Adipose Tissue

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The Afferent Function of Adipose Innervation.

Yu Wang1, Li Ye1

  • 1Department of Neuroscience and Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA.

Diabetes
|February 20, 2024
PubMed
Summary

Sensory nerves in fat tissue, or adipose afferents, play a vital role in energy balance. Further research is needed to understand their function and interactions with other bodily systems.

Area of Science:

  • Physiology
  • Neuroscience
  • Metabolism

Background:

  • Adipose tissue innervation is crucial for metabolic and energy homeostasis.
  • Sympathetic efferent innervation of fat is well-understood, but sensory afferent innervation is less explored.
  • This review focuses on recent advances and open questions in adipose sensory innervation.

Approach:

  • Review of existing literature on adipose tissue innervation.
  • Discussion of recent research on sensory innervation of adipose tissues.
  • Exploration of technical challenges and emerging technologies in studying dorsal root ganglia innervating fat.

Key Points:

  • Adipose afferents' physiological implications in homeostasis require further investigation.
  • Potential crosstalk between adipose afferents, sympathetic neurons, the immune system, and hormonal pathways is a key area of interest.

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Related Experiment Videos

Last Updated: Jul 2, 2025

Co-staining Blood Vessels and Nerve Fibers in Adipose Tissue
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Co-staining Blood Vessels and Nerve Fibers in Adipose Tissue

Published on: February 13, 2019

9.3K
Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue
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Adipo-Clear: A Tissue Clearing Method for Three-Dimensional Imaging of Adipose Tissue

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  • Understanding the technical challenges and utilizing emerging technologies are crucial for advancing research in this field.

    • Conclusions:

    • The role of sensory innervation in adipose tissue function is an emerging area of research.
    • Further investigation into adipose afferents is essential for a comprehensive understanding of metabolic regulation.
    • Identifying and characterizing adipose afferents will open new avenues for therapeutic strategies targeting metabolic disorders.