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Prevalence and predictive factors of colorectal sessile serrated lesions in younger individuals
Jen-Hao Yeh1,2, Chih-Wen Lin3, Po-Jen Hsiao2
1Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Endoscopy
|February 20, 2024
Summary
Sessile serrated lesions (SSLs) are common in younger adults, similar to older individuals. Endoscopist skill and longer withdrawal times are key to detecting these colorectal cancer precursors.
Area of Science:
- Gastroenterology
- Endoscopy
- Colorectal Cancer Prevention
Background:
- Sessile serrated lesions (SSLs) are linked to interval colorectal cancer but their prevalence in younger populations is unknown.
- Understanding SSL risk factors in individuals under 50 is crucial for early detection and prevention.
Purpose of the Study:
- To determine the prevalence of SSLs and clinically significant serrated polyps (CSSPs) in individuals younger than 50 compared to those 50 and older.
- To identify predictors of SSL detection in younger individuals.
Main Methods:
- Retrospective analysis of 9854 colonoscopies.
- Comparison of SSL and CSSP prevalence between younger (<50) and older (≥50) age groups.
- Multivariable logistic regression to identify SSL detection predictors.
Main Results:
- SSL prevalence was similar in younger (7.2%) and older (6.5%) individuals.
- Predictors of SSL detection in younger individuals included age 40-49, longer colonoscopy withdrawal time, and endoscopist performance.
- Adenoma prevalence was lower in younger individuals.
Conclusions:
- SSLs are prevalent in individuals under 50, highlighting the need for vigilant screening.
- Endoscopist expertise and thorough examination are critical for detecting SSLs.
- Further research is needed on the clinical significance of SSLs in younger populations.
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