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UDCA for Drug-Induced Liver Disease: Clinical and Pathophysiological Basis
Fernando Bessone1, Geraldine L Hillotte2, Natalia Ahumada1
1Hospital Provincial del Centenario, Facultad de Ciencias Médicas, Servicio de Gastroenterología y Hepatología, Universidad Nacional de Rosario, Rosario, Argentina.
Seminars in Liver Disease
|February 20, 2024
Summary
Ursodeoxycholic acid (UDCA) shows promise in treating drug-induced liver injury (DILI). This review explores UDCA
Area of Science:
- Hepatology
- Pharmacology
- Toxicology
Background:
- Drug-induced liver injury (DILI) is liver dysfunction caused by medications or xenobiotics.
- DILI presents as hepatocellular (inflammation, necrosis, apoptosis) or cholestatic (bile plugs, duct paucity) injury.
- Ursodeoxycholic acid (UDCA) is used empirically for cholestatic DILI, with emerging evidence for hepatocellular DILI.
Conclusions:
- UDCA possesses multiple hepatoprotective mechanisms applicable to the broad spectrum of DILI.
- UDCA's versatility and safety support its use as a hepatoprotector in DILI.
- Systematic application of UDCA can be rationalized for different DILI types.
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