Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

658
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
658
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.8K
Pharmacodynamics: Overview and Principles01:21

Pharmacodynamics: Overview and Principles

1.1K
Pharmacodynamics is a scientific field that delves into drugs' intricate biochemical, cellular, and physiological effects on the human body. The study of pharmacodynamics helps us understand how drugs interact with the body and elicit various responses.
Most drugs' effects result from their interactions with drug receptors or targets within the body. These interactions trigger specific responses at the cellular or systemic level. Drug receptors can be found on the surfaces of cells or...
1.1K
Factors Influencing Drug Absorption: Disease States and Pharmacology01:25

Factors Influencing Drug Absorption: Disease States and Pharmacology

515
Multiple disease states can significantly influence the oral drug absorption process by affecting blood flow and the functionality of the gastrointestinal (GI) system. Various GI diseases, including conditions that alter GI motility, such as diarrhea, decreased acid secretions (achlorhydria), and infections, have been associated with reduced drug absorption.
Substances such as alcohol and specific drugs, including antineoplastics, can also negatively impact drug absorption. For instance,...
515
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

642
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
642

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Amino acids for renal protection: time to implement in clinical practice.

Korean journal of anesthesiology·2026
Same author

Sex-related mortality differences in septic shock: A propensity score-matched study.

Journal of critical care·2026
Same author

Association of duration of amino acids infusion and renal protection: a secondary analysis of the PROTECTION trial.

British journal of anaesthesia·2026
Same author

Neurocognitive outcomes: methodological clarifications.

Anaesthesia·2026
Same author

Acute normovolaemic haemodilution after cardiac surgery: a meta-analysis of randomised controlled trials.

British journal of anaesthesia·2026
Same author

Diabetes does not modify the renal-protective effect of intravenous amino acids infusion after cardiac surgery.

Journal of endocrinological investigation·2026
Same journal

Intraoperative Lipoproteins Associated with Postoperative Delirium in a Prospective Observational Study of Older Adults Undergoing Cardiac Surgery.

Journal of cardiothoracic and vascular anesthesia·2026
Same journal

Negative-Pressure Lung Re-expansion After One-Lung Ventilation for Pulmonary Resection: A Retrospective Study.

Journal of cardiothoracic and vascular anesthesia·2026
Same journal

Development and Validation of an Integrated Artificial Intelligence-Powered Clinical Decision Support Application for Cardiac Critical Care: Combining Coagulation Management, Blood Gas Analysis, Mechanical Ventilation, Hemodynamic Assessment, and Extracorporeal Membrane Oxygenation.

Journal of cardiothoracic and vascular anesthesia·2026
Same journal

Perioperative Factor VIII Replacement in Severe Hemophilia A During Neonatal Supracardiac Total Anomalous Pulmonary Venous Connection Repair.

Journal of cardiothoracic and vascular anesthesia·2026
Same journal

Effect of the Duration of Cardiopulmonary Bypass on Oxygenation Predicted by Measuring Thoracic Fluid Content Using Electrical Cardiometry in Infants Undergoing Closure of Ventricular Septal Defect:A Prospective Observational Study.

Journal of cardiothoracic and vascular anesthesia·2026
Same journal

Renal Dysfunction Modifies the Prognostic Value of Lactate Clearance in Extracorporeal Cardiopulmonary Resuscitation: A Retrospective Interaction Analysis.

Journal of cardiothoracic and vascular anesthesia·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.0K

Macklin Effect: From Pathophysiology to Clinical Implication.

Matteo Angelini1, Alessandro Belletti2, Giovanni Landoni1

  • 1Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.

Journal of Cardiothoracic and Vascular Anesthesia
|February 20, 2024
PubMed
Summary
This summary is machine-generated.

The Macklin effect, or pulmonary interstitial emphysema, predicts barotrauma in acute respiratory distress syndrome (ARDS) patients. Identifying this CT scan finding can guide ARDS treatment strategies and indicate disease severity.

Keywords:
Macklin effectacute respiratory distress syndromebarotraumaextracorporeal membrane oxygenationmechanical ventilationpneumomediastinum

More Related Videos

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

7.0K
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.3K

Related Experiment Videos

Last Updated: Jul 2, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
07:15

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

11.0K
An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

7.0K
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.3K

Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Critical Care

Background:

  • Air leak syndromes like pneumomediastinum are common in acute respiratory distress syndrome (ARDS) and linked to poorer outcomes.
  • The Macklin effect, characterized by air dissecting along bronchovascular structures, precedes these air leak syndromes.
  • Pneumomediastinum is hypothesized as a severity marker in respiratory failure patients on ventilatory support.

Discussion:

  • The Macklin effect, visible on chest CT scans, signifies air dissection from distal alveoli.
  • It accurately predicts barotrauma in ARDS patients, with high sensitivity and specificity.
  • This finding may serve as a crucial marker for ARDS disease severity.

Key Insights:

  • Chest CT identification of the Macklin effect is key.
  • It shows high accuracy in predicting barotrauma in ARDS.
  • The Macklin effect correlates with disease severity in ARDS.

Outlook:

  • Macklin effect detection can inform ARDS treatment algorithms.
  • It may guide decisions on advanced respiratory monitoring or early intubation.
  • Consideration for early extracorporeal support in severe ARDS is suggested.