A risk model for parenteral nutrition-associated liver disease in patients with severe acute pancreatitis
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View abstract on PubMed
Summary
This summary is machine-generated.Identifying risk factors for parenteral nutrition-associated liver disease (PNALD) in severe acute pancreatitis is crucial. Alcohol intake, elevated ALT, AST, TBIL, and low ALP indicate higher PNALD risk.
Area Of Science
- Hepatology
- Gastroenterology
- Clinical Medicine
Background
- Parenteral nutrition-associated liver disease (PNALD) is a significant complication in patients with severe acute pancreatitis.
- Early identification of risk factors is essential for PNALD prevention and management.
Purpose Of The Study
- To explore and establish a verification risk model for identifying risk factors of PNALD in patients with severe acute pancreatitis.
- To analyze clinical data and laboratory markers associated with PNALD development.
Main Methods
- A cohort of 176 patients with severe acute pancreatitis were divided into PNALD (observation) and non-PNALD (control) groups.
- Clinical data and liver function tests (ALT, AST, TBIL, ALP) were recorded and analyzed using logistic regression and decision tree models.
Main Results
- Patients with PNALD exhibited higher ALT, AST, TBIL, and lower ALP levels compared to the control group.
- Multivariate analysis identified alcohol intake history, ALT ≥69.65 U/L, AST ≥71.27 U/L, TBIL ≥26.27 μmol/L, and ALP ≤45.11 U/L as significant risk factors for PNALD.
Conclusions
- The established risk model demonstrated high consistency between logistic regression and decision tree analyses.
- Alcohol intake, specific thresholds of ALT, AST, TBIL, and ALP are key predictors for PNALD in severe acute pancreatitis patients.
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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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