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Updated: Jul 2, 2025

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miR-142-3p/5p role in cancer: From epigenetic regulation to immunomodulation

Parisa Zareifar1, Hani Moslem Ahmed2, Pouya Ghaderi3

  • 1Golestan University of Medical Science, Gorgan, Golestan, Iran.

Cell Biochemistry and Function
|February 21, 2024
PubMed

Insights

MicroRNAs, specifically miR-142-3p/5p, are key regulators in cancer, acting as oncogenes or tumor suppressors. This review details their roles in gene regulation, immune modulation, and therapeutic potential.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are crucial regulators of gene expression in cancer pathobiology.
  • miR-142-3p/5p is recognized as a significant regulator in various malignancies.
  • Emerging evidence highlights miR-142-3p/5p's dual role as an oncogene or tumor suppressor.

Purpose of the Study:

  • To comprehensively review the multifaceted roles of miR-142-3p/5p in cancer.
  • To summarize its functions in gene regulation, epigenetic modification, and signaling pathways.
  • To explore its immune modulatory effects and implications in tumor escape.

Main Methods:

  • Literature review of current research on miR-142-3p/5p in cancer.
  • Analysis of studies investigating miRNA targeting of epigenetic factors and signaling pathways.
  • Examination of research on the immune modulatory functions of miR-142-3p/5p.

Main Results:

  • miR-142-3p/5p regulates a broad spectrum of downstream genes by targeting epigenetic factors and cancer-related pathways.
  • It plays a critical role in immune modulation, influencing immunosuppression and tumor immune evasion.
  • Exosomes carrying miR-142-3p/5p are involved in intercellular communication, affecting cancer cell behavior.

Conclusions:

  • miR-142-3p/5p exhibits complex functions in cancer, acting as both an oncogene and tumor suppressor.
  • Its immune modulatory properties offer insights into cancer immunology and therapeutic strategies.
  • miR-142-3p/5p holds promise for diagnostic and therapeutic applications in oncology.
Keywords:
cancerepigeneticimmunomodulationmiR-142-3pmiR-142-5p

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