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Related Experiment Video

Updated: Jul 2, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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The connection between epigenetics and gut microbiota-current perspective.

Xingxing Yuan1,2, Yurong Tan3,4, Ousman Bajinka3,4

  • 1Department of Gastroenterology, Heilongjiang Academy of Traditional Chinese Medicine, Harbin, China.

Cell Biochemistry and Function
|February 21, 2024
PubMed
Summary
This summary is machine-generated.

Epigenetic changes and gut microbiota (GM) offer promising biomarkers for diagnosing and treating diseases like metabolic and autoimmune disorders. This review connects these factors, highlighting their role in maternal health and offspring well-being.

Keywords:
diseasesepigenetic changesgut microbiotamulti-omicstherapeutic targets

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Area of Science:

  • Investigates the intersection of epigenetics and gut microbiota (GM) in human health and disease.
  • Focuses on the role of epigenetic modifications and microbial communities in various pathologies.

Background:

  • Epigenetic alterations and GM are increasingly recognized for their roles in disease.
  • Existing research lacks a comprehensive review linking epigenetics and GM as joint biomarkers.
  • Diseases impacted include metabolic, CNS-related, autoimmune, and gastrointestinal disorders.

Purpose of the Study:

  • To provide a detailed review connecting epigenetic modifications and GM.
  • To explore their potential as biomarkers for diagnostics and therapeutics.
  • To examine the influence of maternal GM and epigenetics on offspring health.

Main Methods:

  • Comprehensive literature review of studies on epigenetics and gut microbiota.
  • Analysis of existing data linking epigenetic factors and GM to disease pathogenesis.
  • Exploration of maternal diet's impact on offspring health via GM and epigenetics.

Main Results:

  • Detailed information presented on the interplay between epigenetic factors and GM in disease.
  • Associations identified between maternal GM, epigenetics, and offspring health outcomes.
  • Limitations and future prospects of this emerging interdisciplinary field discussed.

Conclusions:

  • Epigenetics and GM hold significant potential for disease diagnostics, prevention, and treatment.
  • Integrating multi-omics data and longitudinal sampling is crucial for identifying therapeutic targets.
  • Further research is needed to overcome limitations in harnessing these biomarkers effectively.