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Related Experiment Video

Updated: Jul 2, 2025

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Protein succinylation: regulating metabolism and beyond.

Xiaoli Hou1, Yiqiu Chen1, Xiao Li1

  • 1Department of Basic Medicine, Zhengzhou Shuqing Medical College, Zhengzhou, China.

Frontiers in Nutrition
|February 21, 2024
PubMed
Summary

Protein succinylation, a post-translation modification, significantly impacts cellular processes and metabolism. This review explores its roles in regulating glucose, fat, and amino acid metabolism, and related diseases.

Keywords:
metabolismpost-translational modificationredoxregulationsuccinylation

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Post-translational modifications (PTMs) are crucial for protein function and cellular regulation.
  • Over 16 types of PTMs have been identified, with protein succinylation gaining recent attention.
  • Succinylation (Ksuc) involves the modification of protein lysine residues, impacting biological activity, function, and location.

Purpose of the Study:

  • To review the multifaceted roles of protein succinylation in metabolic regulation.
  • To elucidate the involvement of succinylation in glucose, fat, and amino acid metabolism.
  • To highlight the connection between aberrant succinylation and metabolic diseases.

Main Methods:

  • Literature review focusing on recent mass spectrometry analyses and research findings.
  • Analysis of studies investigating the impact of succinylation on cellular processes.
  • Examination of research linking succinylation to metabolic pathways and diseases.

Main Results:

  • Succinylation alters protein conformation, affecting chromatin structure and gene expression.
  • It plays a significant role in cellular proliferation, growth, differentiation, and metabolism.
  • Emerging evidence points to succinylation's primary contribution to metabolic modulations, including enzyme activity and gene expression.

Conclusions:

  • Protein succinylation is a critical PTM with widespread biological implications.
  • It significantly influences metabolic regulation across various pathways.
  • Further research into succinylation is warranted due to its potential role in metabolic diseases.