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Updated: Aug 19, 2026

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
Published on: April 5, 2011
A rational scientific basis for subclassification of antiarrhythmic drugs
Abstract:
The subclassification of Vaughan Williams Class I agents into IA, IB, and IC groups on empiric and clinical grounds has recently been given a cellular electrophysiologic scientific basis. Based on the kinetics of association and dissociation of the drugs with sodium channels, 3 distinct subgroups can be defined. These observations help to explain the clinical utility of the algorithms to use the agents in patients and provide a reference for discussing the new drugs with antiarrhythmic properties being discovered.
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