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Related Experiment Video

Updated: Jul 2, 2025

Implantation of Radiotelemetry Transmitters Yielding Data on ECG, Heart Rate, Core Body Temperature and Activity in Free-moving Laboratory Mice

Implantation of Radiotelemetry Transmitters Yielding Data on ECG, Heart Rate, Core Body Temperature and Activity in Free-moving Laboratory Mice

Published on: November 21, 2011

Measuring Heart Rate in Freely Moving Mice.

Jérémy Signoret-Genest^1,2, Nina Schukraft¹, Philip Tovote¹

¹Institute of Clinical Neurobiology, University Hospital Wuerzburg, Wuerzburg, Germany.

|February 21, 2024

Summary

This summary is machine-generated.

This study details a cost-effective electrocardiogram (ECG) method for measuring heart rate (HR) in mice. The protocol includes equipment fabrication, implantation surgery, and data analysis tools for reliable cardiovascular research.

Keywords:

ECG Freely behaving Heart rate Mouse States

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Analyzing Long-Term Electrocardiography Recordings to Detect Arrhythmias in Mice

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Related Experiment Videos

Last Updated: Jul 2, 2025

Implantation of Radiotelemetry Transmitters Yielding Data on ECG, Heart Rate, Core Body Temperature and Activity in Free-moving Laboratory Mice

Implantation of Radiotelemetry Transmitters Yielding Data on ECG, Heart Rate, Core Body Temperature and Activity in Free-moving Laboratory Mice

Published on: November 21, 2011

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

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Analyzing Long-Term Electrocardiography Recordings to Detect Arrhythmias in Mice

Analyzing Long-Term Electrocardiography Recordings to Detect Arrhythmias in Mice

Published on: May 23, 2021

Area of Science:

Physiology
Neuroscience
Biomedical Engineering

Background:

Heart rate (HR) monitoring is crucial in cardiovascular research and other scientific fields.
Existing methods for measuring HR in behaving mice can be expensive or technically demanding.
Accurate and reliable HR data is essential for understanding physiological responses.

Purpose of the Study:

To provide a comprehensive protocol for measuring heart rate in mice using electrocardiography (ECG).
To describe the fabrication of custom ECG equipment and surgical implantation of electrodes.
To offer user-friendly data processing tools and discuss HR data analysis.

Main Methods:

Development of a step-by-step protocol for manufacturing ECG connectors and shielded cables.
Surgical implantation of subcutaneously placed ECG electrodes for 2-channel differential recording.
Utilization of MATLAB-based graphical user interface (GUI) tools for data acquisition and initial processing.
Application of the protocol in the context of defensive reactions to analyze HR dynamics.

Main Results:

Successful implementation of an inexpensive and easy-to-use ECG technique for up to eight weeks of repeated recordings.
Generation of accurate and reliable heartbeat detection and HR calculation.
Demonstration of the protocol's suitability for recordings challenged by ambient or device noise.
Provision of tools that minimize the need for extensive coding knowledge.

Conclusions:

The described protocol offers a practical and accessible method for long-term HR monitoring in mice.
The provided tools and detailed guidance facilitate accurate data acquisition and analysis.
This technique is valuable for interdisciplinary research, particularly in studies involving behavioral responses and physiological stress.