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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
Melanoma immunotherapy enabled by M2 macrophage targeted immunomodulatory cowpea mosaic virus
Zhongchao Zhao1,2,3, Young Hun Chung3,4, Nicole F Steinmetz1,2,3,4,5,6,7,8
1Department of NanoEngineering, University of California 9500 Gilman Dr, La Jolla San Diego CA 92093 USA nsteinmetz@ucsd.edu.
Abstract:
We have developed nanoparticle formulations targeting M2 macrophages for cancer immunotherapy by conjugating high-affinity binding peptides to cowpea mosaic virus as an immunostimulatory adjuvant. We confirmed the targeting of and uptake by M2 macrophages in vitro and the therapeutic efficacy of the nanoparticles against murine melanoma in vivo.
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