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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Clinicopathological Characteristics And Outcomes Of Colorectal Mucinous Adenocarcinoma: A Retrospective Analysis From China.

Clinicopathological characteristics and outcomes of colorectal mucinous adenocarcinoma: a retrospective analysis from China.

An Huang1, Yong Yang2, Zhuang Sun1

  • 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, Beijing, China.

Frontiers in Oncology
|February 21, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Mucinous adenocarcinoma (MAC) is linked to poorer outcomes in colorectal cancer patients compared to non-mucinous adenocarcinoma (NMAC). However, MAC patients, especially those with advanced disease, can still benefit from adjuvant chemotherapy.

Area of Science:

  • Oncology
  • Gastroenterology
  • Cancer Research

Background:

  • Mucinous adenocarcinoma (MAC) is a distinct subtype of colorectal cancer.
  • The prognostic significance of MAC compared to non-mucinous adenocarcinoma (NMAC) is debated.

Purpose of the Study:

  • To compare clinicopathological features and prognostic outcomes between MAC and NMAC.
  • To identify factors influencing survival in colorectal adenocarcinoma patients.

Main Methods:

  • Retrospective analysis of 77 MAC and 674 NMAC patients (2016-2019).
  • Univariate and multivariate Cox regression, propensity score matching (PSM) for prognostic factor analysis.
  • Construction of nomograms for overall survival (OS) and cancer-specific survival (CSS).

Main Results:

Keywords:
colorectal cancermucinous adenocarcinomanomogramprognosis

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  • MAC patients exhibited larger tumors, advanced T stage, higher metastasis rates, and elevated CEA.
  • MAC was associated with significantly worse OS and CSS, persisting after PSM.
  • Subgroup analysis revealed poorer survival for left-sided or stage III/IV MAC. Adjuvant chemotherapy improved survival in specific stages.

Conclusions:

  • MAC is an independent risk factor for poor prognosis in colorectal adenocarcinoma, especially for left-sided and advanced stage disease.
  • Despite poorer prognosis, MAC patients can benefit from adjuvant chemotherapy.
propensity score matching