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Relation between LRG1 and CD4+ T cells, cognitive impairment and neurological function in patients with acute
Xiao Cheng1,2, Hongen Wei1,2, Yi Liu1
1Department of Neurology, The Fifth Clinical Medical College of Shanxi Medical University (Fifth Hospital of Shanxi Medical University), Taiyuan, 030009, China.
Biomarkers in Medicine
|February 21, 2024
Summary
Leucine-rich alpha-2 glycoprotein 1 (LRG1) levels correlate with specific T cell populations and predict cognitive impairment and poor neurological recovery in acute ischemic stroke patients. Higher LRG1 indicates worse outcomes.
Area of Science:
- Neuroscience
- Immunology
- Cardiovascular Medicine
Background:
- Acute ischemic stroke (AIS) poses significant challenges to neurological function and cognitive health.
- T cell subsets, including Th17, Th2, and regulatory T cells (Tregs), play critical roles in the inflammatory response following stroke.
- Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a protein implicated in various biological processes, but its role in AIS is not fully understood.
Purpose of the Study:
- To investigate the association between LRG1 levels and CD4+ T cell subsets in patients with AIS.
- To determine the relationship between LRG1 and cognitive impairment and neurological function recovery post-AIS.
Main Methods:
- Plasma LRG1 concentrations were measured using ELISA in 175 AIS patients at multiple time points (baseline, day 1, day 7, month 1, and month 3).
- T cell subsets (Th17, Th2, Treg) were analyzed in relation to LRG1 levels.
- Cognitive function and neurological status were assessed at 3 months post-stroke.
Main Results:
- LRG1 levels showed a negative correlation with Th2 and Treg cells and a positive correlation with Th17 cells (p < 0.05).
- LRG1 concentrations exhibited a dynamic pattern, increasing from baseline to day 1, then decreasing through month 3 (p < 0.001).
- Elevated LRG1 levels at all measured time points were significantly associated with the presence of cognitive impairment and poorer neurological function at 3 months (p < 0.05).
Conclusions:
- LRG1 is significantly associated with altered T cell profiles, specifically decreased Th2 and Treg cells and increased Th17 cells, in AIS patients.
- LRG1 serves as a potential biomarker for predicting cognitive impairment and suboptimal neurological recovery following acute ischemic stroke.
- These findings highlight LRG1's role in the immunopathology of AIS and its implications for patient outcomes.
Keywords:
CD4+ T cellsLRG1acute ischemia strokecluster of differentiation 4+ T cellscognitive impairmentleucine-rich alpha-2-glycoprotein1neurological functionMore Related Videos
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