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Updated: Aug 11, 2026

High-throughput Screening of Carbohydrate-degrading Enzymes Using Novel Insoluble Chromogenic Substrate Assay Kits
Published on: September 20, 2016
Identification of ß-Glucocerebrosidase Activators for Glucosylceramide hydrolysis
Monika-Sarah E D Schulze1, Diana Scholz2, Eric Jnoff2
1UCB, 216 Bath Road, Slough, SL1 3WE, UK.
Abstract:
Several novel chemical series were identified that modulate glucocerebrosidase (GCase). Compounds from these series are active on glucosylceramide, unlike other known GCase modulators. We obtained GCase crystal structures with two compounds that have distinct chemotypes. Positive allosteric modulators bind to a site on GCase and induce conformational changes, but also induce an equilibrium state between monomer and dimer.
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