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Related Experiment Videos

Gut-liver interaction during accelerated gluconeogenesis.

W W Souba, D W Wilmore

    Archives of Surgery (Chicago, Ill. : 1960)
    |January 1, 1985
    PubMed
    Summary

    Dexamethasone alters glucose metabolism in visceral organs. The gastrointestinal tract and kidneys shift from glucose consumption to release, impacting overall glucose dynamics during catabolic states.

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    Area of Science:

    • Metabolic Physiology
    • Endocrinology

    Background:

    • Catabolic states, such as sepsis, are characterized by altered glucose metabolism.
    • Glucocorticoids like dexamethasone are potent regulators of glucose homeostasis.

    Purpose of the Study:

    • To investigate the impact of dexamethasone sodium phosphate on glucose, glutamine, and alanine exchange across visceral organs.
    • To elucidate the role of the gastrointestinal tract, liver, and kidneys in dexamethasone-induced metabolic changes.

    Main Methods:

    • Utilized long-term catheterized awake dogs (n=25).
    • Measured substrate exchange (glucose, glutamine, alanine) across the GI tract, liver, and kidneys.
    • Administered dexamethasone sodium phosphate (0.44 mg/kg/day) for 2 and 9 days, comparing to a control period.

    Main Results:

    • Dexamethasone treatment shifted the GI tract from glucose consumption to balance or release.
    • Gut glutamine consumption and intestinal alanine release significantly increased with dexamethasone.
    • Hepatic glucose production more than doubled, accompanied by increased hepatic alanine uptake.
    • Kidneys transitioned from glucose balance to glucose release by day 9 of dexamethasone treatment.

    Conclusions:

    • The gastrointestinal tract and kidneys are key players in altered glucose dynamics during dexamethasone treatment.
    • These findings offer insights into the metabolic derangements observed in catabolic conditions like sepsis.

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