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Clonorchis sinensis on the prognosis of patients with spontaneous rupture of Hepatocellular Carcinoma: An inverse
Hang-Hang Ni1,2, Zhan Lu1, Cheng-Lei Yang1
1Department of Hepatobiliary Surgery, Guangxi Medical University Cancer Hospital, Nanning, People's Republic of China.
Plos Neglected Tropical Diseases
|February 21, 2024
Summary
Clonorchis sinensis infection negatively impacts overall survival in patients with spontaneous rupture Hepatocellular Carcinoma (srHCC) undergoing surgery. This parasitic infection is a significant risk factor for poorer outcomes in srHCC patients.
Area of Science:
- Hepatobiliary surgery
- Infectious disease pathology
- Oncology
Background:
- Spontaneous rupture Hepatocellular Carcinoma (srHCC) presents unique challenges in surgical management.
- The role of parasitic infections, specifically Clonorchis sinensis (C. sinensis), in srHCC outcomes remains under-investigated.
Purpose of the Study:
- To investigate the impact of C. sinensis infection on the survival of srHCC patients undergoing hepatectomy.
- To determine if C. sinensis infection is an independent prognostic factor for srHCC patients.
Main Methods:
- A cohort of 157 srHCC patients undergoing hepatectomy were analyzed.
- Inverse probability of treatment weighting (IPTW) was used to adjust for preoperative differences.
- Overall survival (OS) and recurrence-free survival (RFS) were compared, with multivariate Cox regression analysis performed.
Main Results:
- After IPTW, patients with C. sinensis infection had significantly worse median OS (9 months) compared to those without (29 months).
- C. sinensis infection was associated with poorer OS (p=0.024) but not RFS (p=0.065).
- Multivariate analysis identified C. sinensis infection and younger age as independent predictors of worse OS.
Conclusions:
- Clonorchis sinensis infection adversely affects overall survival in srHCC patients treated with hepatectomy.
- Parasitic infection should be considered a critical prognostic factor in srHCC management.
