Improving respiratory signal prediction with a deep neural network and simple changes to the input and output data...

Objective.To improve respiratory gating accuracy and radiation treatment throughput, we developed a generalized model based on a deep neural network (DNN) for predicting any given patient's respiratory motion.Approach.Our model uses long short-term memory (LSTM) based on a recurrent neural network (RNN), and improves upon common techniques. The first improvement is that the data input is not a one-dimensional sequence, but two-dimensional block data. This shortens the input sequence length, reducing computation time. Second, the output is not a scalar, but a sequence prediction. This increases the amount of available data, allowing improved prediction accuracy. For training and evaluation of our model, 434 sets of real-time position management data were retrospectively collected from clinical studies. The data were separated in a ratio of 4:1, with the larger set used for training models and the remaining set used for testing. We measured the accuracy of respiratory signal prediction and amplitude-based gating with prediction windows equaling 133, 333, and 533 ms. This new model was compared with the original LSTM and a non-recurrent DNN model.Main results.The mean absolute errors with the prediction window at 133, 333 and 533 ms were 0.036, 0.084, 0.119 with our model; 0.049, 0.14, 0.246 with the original LSTM-based model; and 0.041, 0.119, 0.16 with the non-recurrent DNN model, respectively. The computation time were 0.66 ms with our model; 0.63 ms the original LSTM-based model; 1.60 ms the non-recurrent DNN model, respectively. The accuracies of amplitude-based gating with the same prediction window settings and a duty cycle of approximately 50% were 98.3%, 95.8% and 92.7% with our model, 97.6%, 93.9% and 87.2% with the original LSTM-based model; and 97.9%, 94.3% and 89.5% with the non-recurrent DNN model, respectively.Significance.Our RNN algorithm for respiratory signal prediction successfully estimated tumor positions. We believe it will be useful in respiratory signal prediction technology.