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Multi-omics analysis-based macrophage differentiation-associated papillary thyroid cancer patient classifier
Hanlin Sun1, Zhengyan Chang2, Hongqiang Li1
1Department of Thyroid Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, PR China.
Translational Oncology
|February 21, 2024
Summary
This study introduces a new classification for Papillary Thyroid Carcinoma (PTC) based on immune status and macrophage differentiation, identifying three distinct subtypes (ISMPTCC, INMPTCC, IAMPTCC) for improved understanding of thyroid cancer prognosis.
Area of Science:
- Oncology
- Immunology
- Genomics
Background:
- Papillary Thyroid Carcinoma (PTC) reclassification is crucial.
- Thyroid cancer prognosis is linked to inflammation and immune responses.
- Macrophage differentiation offers a novel approach for PTC subtyping.
Purpose of the Study:
- To develop a new classification system for Papillary Thyroid Carcinoma (PTC) based on immune status and macrophage differentiation.
- To investigate the immunological mechanisms underlying differential prognosis of thyroid tumors.
- To subtype PTC using macrophage differentiation characteristics.
Main Methods:
- Single-cell RNA sequencing and bulk sequencing data analysis.
- Dimensionality reduction, clustering, and differential gene expression analysis.
- Cell differentiation trajectory analysis, multi-omics analysis, and immunohistochemistry validation.
Main Results:
- Identification of key transcription factors, immune cells/functions, and signaling pathways.
- Construction of regulatory networks for three Immune status and Macrophage differentiation-associated Papillary Thyroid Cancer Classification (IMPTCC) clusters.
- Validation of pathological histology through immunohistochemistry.
Conclusions:
- Identification of three IMPTCC subtypes: Immune-Suppressive (ISMPTCC), Immune-Neutral (INMPTCC), and Immune-Activated (IAMPTCC).
- Each subtype displays unique metabolic, immune, and regulatory profiles.
- These subtypes correlate with distinct macrophage differentiation states, offering insights into PTC prognosis.
