Related Experiment Video
Updated: Jul 2, 2025

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
Published on: October 11, 2019
Coagulation factor V in breast cancer: a p53-regulated tumor suppressor and predictive marker for treatment response
Sara Marie Lind1, Marit Sletten1, Mona Hellenes1
1Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway.
Coagulation Factor V (FV) is a potential tumor suppressor in breast cancer, with its expression linked to chemotherapy response. This study reveals FV as a p53-regulated marker with therapeutic implications.
Area of Science:
- Oncology
- Hematology
- Molecular Biology
Background:
- Cancer patients face heightened risks of coagulation complications, exacerbated by chemotherapy.
- Tumor progression is intricately linked with the hemostatic system.
- Breast cancer cells express coagulation Factor V (FV), a key coagulation protein.
Purpose of the Study:
- Investigate the role of FV in breast cancer progression.
- Explore associations between FV and chemotherapy treatment response.
- Examine gene regulation and functional effects of FV during chemotherapy.
Main Methods:
- Utilized receiver operating characteristic plotter to assess FV mRNA (F5) expression as a predictor for FEC chemotherapy response.
- Analyzed breast cancer cohorts for treatment response to FEC.
- Investigated chemotherapy's effect on F5 expression, F5 regulation, and FV's functional impact in breast cancer cell lines.
Main Results:
- Higher F5 tumor expression was observed in FEC responders compared to non-responders.
- Anthracycline treatment in vitro increased F5 expression, modulated by p53.
- FV overexpression demonstrated a slight reduction in proliferation and increase in apoptosis during anthracycline treatment.
Conclusions:
- Identified F5 as a p53-regulated tumor suppressor candidate.
- F5 is a promising biomarker for predicting chemotherapy response in breast cancer.
- FV exhibits functional effects with potential therapeutic relevance in breast cancer treatment.
More Related Videos
Related Concept Videos
Abnormal Proliferation
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Negative Regulator Molecules
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...

