A rapid, universal TI-59 model-independent pharmacokinetic analysis program based on statistical moment theory

A model-independent program for pharmacokinetic analyses based on statistical moment theory is presented and demonstrated. The program uses an inexpensive and portable TI-59; a PC-100A printer adds convenience but is optional. The program may be used in analysis of blood, serum, or plasma concentration vs. time curves originating from iv, im, po, sl, or sc administration. Drug input can be zero or first order; both single-dose and multiple-dose steady-state conditions can be evaluated. A comparison between results generated using moment analysis and traditional two-compartment nonlinear regression showed excellent agreement.