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Related Concept Videos

Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

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The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
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Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

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Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
416
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
326
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
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Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

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Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
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Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
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RE.GA.IN.: the Real-world Gastritis Initiative-updating the updates.

Massimo Rugge1,2, Robert M Genta3,4, Peter Malfertheiner5,6

  • 1Department of Medicine-DIMED, University of Padova, Padua, Italy massimo.rugge@unipd.it.

Gut
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Summary

The Real-world Gastritis Initiative (RE.GA.IN.) provides updated, patient-centered guidelines for diagnosing and managing gastritis, focusing on Helicobacter pylori, autoimmunity, and microbiota. These evidence-based statements aid healthcare professionals in clinical practice.

Keywords:
AUTOIMMUNITYGASTRIC CARCINOMAGASTRIC PRE-CANCERGASTROINTESTINAL PATHOLOGYHELICOBACTER PYLORI - GASTRITIS

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Area of Science:

  • Gastroenterology
  • Pathology
  • Microbiology

Background:

  • Gastritis classification has evolved through key international initiatives since the Sydney classification.
  • Recent advancements necessitate updated clinical consensus on gastritis diagnosis and management.
  • The Real-world Gastritis Initiative (RE.GA.IN.) convened experts to address current clinicopathological challenges.

Purpose of the Study:

  • To synthesize current knowledge on gastritis epidemiology, etiology, and pathophysiology.
  • To provide evidence-based, patient-centered statements for clinical practice.
  • To guide healthcare professionals in the diagnosis and management of gastritis.

Main Methods:

  • Multidisciplinary consensus process involving global gastritis scholars.
  • Review of epidemiology, Helicobacter pylori's role, gastric autoimmunity, and microbiota.
  • Discussion of diagnostic endoscopy and histological staging.

Main Results:

  • Helicobacter pylori identified as the primary cause of environmental gastritis and a key factor in gastric cancer development.
  • Evolving understanding of gastric autoimmunity and the clinicopathological significance of gastric microbiota.
  • Emphasis on the diagnostic value of endoscopy and the importance of histological staging.

Conclusions:

  • RE.GA.IN. provides updated, actionable insights into gastritis management.
  • The consensus promotes improved clinical decision-making for patients with gastritis.
  • Focus on integrating epidemiology, etiology, diagnostics, and prognosis for comprehensive care.