Intraoperative hypotension and postoperative acute kidney injury: A systematic review

There is no consensus regarding safe intraoperative blood pressure thresholds that protect against postoperative acute kidney injury (AKI). This review aims to examine the existing literature to delineate safe intraoperative hypotension (IOH) parameters to prevent postoperative AKI.

PubMed, Cochrane Central, and Web of Science were systematically searched for articles published between 2015 and 2022 relating the effects of IOH on postoperative AKI.

Our search yielded 19 articles. IOH risk thresholds ranged from <50 to <75 ​mmHg for mean arterial pressure (MAP) and from <70 to <100 ​mmHg for systolic blood pressure (SBP). MAP below 65 ​mmHg for over 5 ​min was the most cited threshold (N ​= ​13) consistently associated with increased postoperative AKI. Greater magnitude and duration of MAP and SBP below the thresholds were generally associated with a dose-dependent increase in postoperative AKI incidence.

While a consistent definition for IOH remains elusive, the evidence suggests that MAP below 65 ​mmHg for over 5 ​min is strongly associated with postoperative AKI, with the risk increasing with the magnitude and duration of IOH.