Related Experiment Video
Updated: Jul 2, 2025
03:33
Author Spotlight: Advancing Hepatobiliary and Pancreatic Tumor Treatment with Minimally Invasive Surgical Techniques
Published on: September 27, 2024
818
Total laparoscopic partial hepatectomy versus open partial hepatectomy for primary left-sided hepatolithiasis: study
Shu-Bo Pan1, Chun-Li Wu1, Da-Chen Zhou1
1Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Furong Road 678#, Shushan District, Hefei, 230601, Anhui, China.
Trials
|February 21, 2024
Summary
Laparoscopic left-sided hepatectomy (LLH) offers comparable outcomes to open surgery for hepatolithiasis. This randomized controlled trial will confirm LLH benefits within enhanced recovery programs, evaluating length of stay and long-term results.
Area of Science:
- Hepatobiliary surgery
- Minimally invasive surgery
- Gastroenterology
Background:
- Hepatolithiasis treatment often involves surgical intervention.
- Laparoscopic left-sided hepatectomy (LLH) potential benefits over open surgery lack robust randomized controlled trial (RCT) evidence.
- Enhanced recovery after surgery (ERAS) programs are increasingly adopted for liver resections.
Purpose of the Study:
- To compare the safety and effectiveness of LLH versus open left-sided hepatectomy (OLH) for hepatolithiasis.
- To evaluate outcomes including length of hospital stay (LOS), morbidity, and long-term complications.
- To provide evidence for LLH within ERAS programs.
Main Methods:
- A prospective randomized controlled trial (RCT) comparing LLH and OLH in a 1:1 ratio.
- Patients with hepatolithiasis eligible for left-sided hepatectomy will be recruited.
- Primary outcome is length of hospital stay (LOS); secondary outcomes include morbidity, readmission, and long-term hernia incidence.
Main Results:
- Sample size of 86 patients per arm calculated to detect a 1-day reduction in LOS.
- Trial aims to provide evidence for laparoscopic surgery in liver resection within ERAS.
- Study will assess short- and long-term outcomes.
Conclusions:
- LLH outcomes are comparable to OLH in retrospective studies.
- LLH use is limited due to lack of RCT data in ERAS programs.
- This RCT will evaluate surgical and long-term outcomes of LLH compared to OLH for hepatolithiasis within ERAS.
