Multiple primary head and neck squamous cell cancer: Lessons learnt

Area of Science:

• Oncology
• Head and Neck Surgery
• Cancer Research

Background:

• Multiple primary head and neck squamous cell cancer (MPHNSCC) presents a significant clinical challenge.
• Understanding the demographic profile and treatment outcomes is vital for improving patient management.

Purpose of the Study:

• To analyze the demographic characteristics, treatment outcomes, and influencing factors in patients diagnosed with MPHNSCC.
• To identify key factors affecting treatment success in MPHNSCC cases.

Main Methods:

• Retrospective analysis of hospital records for histopathology-proven MPHNSCC cases from January 2008 to December 2020.
• Utilized Modified Warren-Gates criteria for MPHNSCC definition and analyzed demographic and clinical data.

Main Results:

• The study included 27 MPHNSCC patients, with a median age of 50; 63% were tobacco users.
• The oral cavity was the most common site for both index and second primary malignancies, often presenting at locally advanced stages.
• Metachronous presentation (89%) was most common, with 67% alive with disease and 26% alive without disease at follow-up.

Conclusions:

• MPHNSCC frequently originates in the oral cavity and is often diagnosed at advanced stages, despite accessibility for self-examination.
• There is a clear need for enhanced patient education and increased physician awareness regarding MPHNSCC for earlier diagnosis.