Bilateral carpal tunnel syndrome caused by Graves' disease

We observed three patients in whom carpal tunnel syndrome (CTS) developed in association with hyperthyroidism (Graves' disease). The course of one of these patients was marked by resolution of symptoms and electrophysiologic measures of CTS that paralleled the remission of Graves' disease after treatment with radioactive iodine. No other treatment of CTS was required or given. There may be a causal relationship between Graves' disease and CTS.