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Study and analysis of the correlation between lumbar spondylolisthesis and Modic changes
Guang-Qing Li1, Xiao Kang1, Wei Li2
1Spine Surgery Department, The Fourth People's Hospital of Hengshui, Hengshui, China.
Frontiers in Surgery
|February 22, 2024
Summary
Modic changes in lumbar spondylolisthesis are linked to younger age and better bone density. Key risk factors include disc degeneration, spondylolisthesis type and degree, reduced disc height, and altered disc angle.
Area of Science:
- Orthopedics
- Radiology
- Spine Surgery
Background:
- Lumbar spondylolisthesis is a common spinal condition.
- Modic changes are bone marrow signal abnormalities observed on MRI, often associated with degenerative disc disease.
- Understanding the risk factors for Modic changes in lumbar spondylolisthesis is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate the risk factors associated with the development of Modic changes in patients with lumbar spondylolisthesis.
- To analyze the correlation between Modic changes and various clinical and imaging parameters.
Main Methods:
- Retrospective analysis of patients with lumbar spondylolisthesis.
- Assessment of Modic change distribution, spondylolisthesis type and grade, and intervertebral disc degeneration using MRI.
- Statistical analysis, including logistic regression, to identify significant risk factors.
Main Results:
- Patients with Modic changes were younger and had higher bone mineral density compared to those without.
- Significant differences were observed in intervertebral disc height (IDH) and disc angle between groups.
- Modic changes, particularly Type II, were more prevalent in isthmic spondylolisthesis and increased with the severity of spondylolisthesis and disc degeneration.
Conclusions:
- Modic changes in lumbar spondylolisthesis are associated with younger age and better bone density.
- Key risk factors include the type and degree of spondylolisthesis, intervertebral disc degeneration, reduced intervertebral disc height, and altered local stress angulation (disc angle).
- These findings aid in understanding the pathogenesis and predicting the occurrence of Modic changes in this patient population.
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