Fast algorithms for the analysis of sino-atrial node function

The calculations of parameters of the sino-atrial node function have previously required the application of a non-linear least squares curve-fitting algorithm. We have compared five algorithms, three of which eliminate the need for direct non-linear least squares routines. The fast algorithms can provide greater accuracy while using less than 10% of the computing time. They make it feasible to provide real-time analysis during clinical electrophysiological studies.