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Liver Transplant for Hepatocellular Carcinoma in Post-Milan Criteria Era: A Long-Term Single-Center Experience

  • 0From the Liver Transplantation Research Center, Tehran University of Medical Sciences, and the and Hepatobiliary Surgery and Liver Transplantation Division, Department of General Surgery, Imam Khomeini Hospital Complex, Tehran, Iran.
Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation +

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February 22, 2024

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February 22, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Liver transplant outcomes for hepatocellular carcinoma (HCC) patients are acceptable post-Milan criteria. Survival rates were comparable between HCC patients and controls, with low recurrence rates.

Area Of Science

  • Hepatology
  • Transplant Surgery
  • Oncology

Background

  • Hepatocellular carcinoma (HCC) is a leading cause of liver cirrhosis.
  • Liver transplantation is a curative option for select HCC patients.
  • The Milan criteria guide HCC patient selection for liver transplantation.

Purpose Of The Study

  • To investigate the outcomes of liver transplantation in patients with hepatocellular carcinoma.
  • To compare survival rates between HCC patients and non-HCC patients undergoing liver transplant.
  • To assess the recurrence rate of HCC post-transplantation.

Main Methods

  • Prospective study of deceased donor liver transplant recipients from 2007-2021.
  • Patients with HCC were selected based on Milan criteria.
  • HCC patients received mechanistic target of rapamycin inhibitor and calcineurin inhibitor minimization post-transplant.

Main Results

  • 82 HCC patients and 1076 controls were included; 92.68% of HCC patients met Milan criteria.
  • Median follow-up was 65.3 months.
  • Patient survival rates at 3 months, 1 year, and 3 years were similar between HCC (89%, 80%, 78%) and control (84%, 81%, 70%) groups (P=.742).
  • HCC recurrence occurred in 7.31% of patients at a mean of 16.83 months postoperatively.

Conclusions

  • Liver transplantation for HCC patients in the post-Milan criteria era yields acceptable outcomes.
  • Survival rates are comparable to non-HCC transplant recipients.
  • HCC recurrence rates are low, supporting transplantation for selected HCC patients.