"Clickable" graphene nanoribbons for biosensor interfaces

Area of Science:

• Materials Science
• Nanotechnology
• Biotechnology

Background:

• Graphene nanoribbons (GNRs) offer unique electronic and optical properties.
• Developing robust and versatile interfaces for biosensors is crucial for sensitive analyte detection.

Purpose of the Study:

• To synthesize
• clickable
• GNRs for biosensor applications.
• To investigate GNRs as an interface for electrochemical biosensors and field-effect transistors (FETs).
• To explore the potential for simultaneous optical and electronic probing using GNRs.

Main Methods:

• Synthesis of
• clickable
• GNRs.
• Deposition of GNRs on gold-coated electrodes.
• Covalent anchoring of DNA aptamers as bioreceptors.
• Integration of GNRs into reduced graphene oxide (rGO)-based FETs.

Main Results:

• GNRs facilitated selective and sensitive detection of Interleukin 6 (IL6).
• GNRs provided a more robust interface compared to conventional linkers in rGO-FETs.
• GNRs enabled orthogonal and covalent attachment with higher probe density.
• GNRs introduced photoluminescence (PL) in rGO-based FETs.

Conclusions:

• "Clickable" GNRs serve as a versatile platform for electrochemical biosensors.
• GNRs enhance the performance and robustness of biosensor interfaces.
• GNRs enable simultaneous optical and electronic detection, opening new avenues for bioanalytical tools.