Implementing GRADE in systematic reviews that adhere to JBI methodological conduct.

Area of Science:

• Health research methodology
• Evidence synthesis
• Clinical guideline development

Background:

• The Grading of Recommendations Assessment, Development and Evaluation (GRADE) is a widely adopted framework for assessing the certainty of evidence.
• Joanna Briggs Institute (JBI) is a global organization providing methods for evidence synthesis.
• GRADE is currently endorsed for specific JBI systematic reviews.

Purpose of the Study:

• To clarify the implementation of the GRADE approach within JBI's systematic review methodology.
• To address uncertainties regarding the application of GRADE in JBI reviews.

Main Methods:

• This study involves a methodological review and synthesis of existing JBI and GRADE guidelines.
• Analysis of JBI's systematic review protocols and GRADE working group recommendations.
• Identification of potential integration points and challenges.

Main Results:

• The GRADE approach is endorsed for a subset of JBI systematic reviews.
• There is a need for clearer guidance on when and how to apply GRADE within JBI methodology.
• Potential for enhanced consistency in evidence appraisal across different synthesis frameworks.

Conclusions:

• Further clarification is needed to effectively integrate GRADE into all JBI systematic reviews.
• Standardizing the application of GRADE within JBI methodology will improve evidence certainty.
• This work aims to support researchers in applying GRADE consistently within JBI reviews.