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Diagnostic, Therapeutic, and Theranostic Multifunctional Microneedles
Yavuz Nuri Ertas1,2,3, Derya Ertas2, Ahmet Erdem4,5
1Department of Biomedical Engineering, Erciyes University, Kayseri, 38039, Türkiye.
Small (Weinheim an Der Bergstrasse, Germany)
|February 22, 2024
Summary
Microneedles (MNs) are evolving into smart, multifunctional devices for drug delivery and diagnostics. This review explores their development for advanced medical applications, promising future integration into standard healthcare.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Microneedles (MNs) are popular for minimally invasive therapeutic and diagnostic applications.
- Originally metal, MNs are now polymer-based, offering biocompatibility and cost-effectiveness.
- Current advancements focus on intelligent MNs with enhanced functionalities.
Purpose of the Study:
- To provide a comprehensive review of microneedle (MN) functions and their evolution.
- To discuss the development of smart and multifunctional MNs for novel applications.
- To examine fabrication techniques, applications, and experimental details of advanced MN constructs.
Main Methods:
- Literature review of microneedle fabrication and applications.
- Analysis of individual MN functions and their integration into multifunctional systems.
- Examination of concurrent capabilities such as sensing, drug delivery, and sampling.
Main Results:
- Microneedles have evolved from simple drug delivery devices to complex, multifunctional systems.
- Advanced MNs incorporate sensing, bodily fluid extraction, and remote communication.
- Fabrication techniques and materials are advancing for enhanced performance and biocompatibility.
Conclusions:
- Smart, multifunctional microneedles represent a significant advancement in medical technology.
- These devices show great potential for diverse applications in diagnostics and therapeutics.
- MN-based smart devices are poised to become integral to future medical practices.
