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Updated: Jul 2, 2025

Radiosynthesis, Quality Control, and Small Animal Positron Emission Tomography Imaging of 68Ga-Labelled Nano Molecules
Published on: October 4, 2024
A novel radiolabelled salmochelin derivative for bacteria-specific PET imaging: synthesis, radiolabelling and
Renato Margeta1, Sonja Schelhaas1, Sven Hermann1
1European Institute for Molecular Imaging (EIMI), University Münster, Röntgenstraße 16, 48149, Münster, Germany.
Abstract:
For specific imaging of bacterial infections we aimed at targeting the exclusive bacterial iron transport system via siderophore-based radiotracers. De novo synthesis and radiolabeling yielded the salmochelin-based PET radiotracer [68Ga]Ga-RMA693, which showed a favourable biodistribution and a bacteria-specific uptake in an animal model of Escherichia coli infection.
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