Related Experiment Video

Updated: Jul 2, 2025

Laboratory Scale Production and Purification of a Therapeutic Antibody
09:54

Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

17.4K

Taming the beast: engineering strategies and biomedical potential of antibody-based cytokine mimetics

Lukas Pekar1, Simon Krah1, Stefan Zielonka1,2

  • 1Antibody Discovery & Protein Engineering, Merck Healthcare KGaA, Darmstadt, Germany.

Expert Opinion on Biological Therapy
|February 22, 2024
PubMed
Abstract

No abstract available in PubMed .

Keywords:
AntibodyVHHantibody engineeringbispecific antibodycytokinecytokine mimeticsingle domain antibodysurrogate agonist

More Related Videos

Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments
12:28

Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments

Published on: October 15, 2016

11.5K
In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
07:25

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

Published on: May 4, 2017

17.8K

Related Experiment Videos

Last Updated: Jul 2, 2025

Laboratory Scale Production and Purification of a Therapeutic Antibody
09:54

Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

17.4K
Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments
12:28

Bacterial Inner-membrane Display for Screening a Library of Antibody Fragments

Published on: October 15, 2016

11.5K
In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
07:25

In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis

Published on: May 4, 2017

17.8K

Related Concept Videos

Hybridoma Technology01:31

Hybridoma Technology

14.7K
Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
14.7K

Articles linked to this work by shared authors, journal, and citation graph.

LIF and let die: Generation, mechanistical and structural characterization of bispecific antibodies triggering leukemia inhibitory factor (LIF) receptor activation independent of the cytokine LIF.

The Journal of biological chemistry·2026

Becoming the bull: Structural insights and engineering strategies for ultralong CDR-H3 paratopes from cattle.

FEBS letters·2026

Antibody framework engineering enables augmented cytokine receptor signaling capacities of bispecific single domain antibody-based IL-21 mimetics.

mAbs·2026

Simultaneous targeting of IL-10 and PD-(L)1 pathways with a bispecific anti-PD-L1/IL-10-trap antibody enhances T cell responses.

Molecular therapy. Oncology·2026

Protocol for in vitro profiling of key TNF downstream signaling pathways involved in cell death and pro-survival signaling in cancer cells.

STAR protocols·2026

Generation and Characterization of Bispecific VHH-Derived Surrogate Agonists Mimicking the Function of IL-18.

Methods in molecular biology (Clifton, N.J.)·2026

An evaluation of marnetegragene autotemcel for the treatment of severe leukocyte adhesion deficiency type I.

Expert opinion on biological therapy·2026

Biologics in alopecia areata: promise, paradox, and the precision medicine frontier.

Expert opinion on biological therapy·2026

Current and emerging sublingual immunotherapies for dust mite allergy.

Expert opinion on biological therapy·2026

An evaluation of sacituzumab tirumotecan for the treatment of NSCLC.

Expert opinion on biological therapy·2026

Emerging therapeutic strategies and clinical trials in severe asthma management: current evidence and future directions.

Expert opinion on biological therapy·2026

The cost of delay: foregone public expenditure savings from delayed adalimumab biosimilar listing in Australia's Pharmaceutical Benefits Scheme.

Expert opinion on biological therapy·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us