Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Computer-assisted analysis in organic synthesis.

E J Corey, A K Long, S D Rubenstein

    Science (New York, N.Y.)
    |April 26, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Highly Enantioselective Oxidation Reactions Using a Tetradentate Mn(II) Catalyst Based on (<i>S</i>,<i>S</i>)-1,2-Diaminocyclohexane.

    Organic letters·2026
    Same author

    Enantioselective Catalytic Oxidation of Olefins and Organosulfur Compounds by Chiral Mn(II) Diamino-Dicarboxylato or Disulfonato Complexes via a Pentacoordinate Mn(V)-Oxo Cation.

    Organic letters·2026
    Same author

    Experimental Support for a Chiral Pentacoordinate, Axially Symmetric Cationic Mn(V)-Oxo Complex as the Key Reactant in the Highly Enantioselective Catalytic Epoxidation of Olefins.

    Organic letters·2026
    Same author

    Highly Position- and Enantioselective Catalytic Epoxidation of Polyolefins Mediated by a Chiral Mn Complex, Including a One-Step Conversion of Squalene to the (<i>S</i>)-2,3-Epoxide, a Precursor of Natural Steroids and Terpenoids.

    Journal of the American Chemical Society·2025
    Same author

    Synthetically Useful Transformations of Olefins via Cationic 1,2-Oxazetium Intermediates.

    Organic letters·2023
    Same author

    Synthesis of Tetracyclic <i>C</i><sub>2</sub>-Symmetric Ketiminium Salts and Evaluation as Catalysts for Epoxidation.

    Organic letters·2023
    Same journal

    Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

    Science (New York, N.Y.)·2026
    Same journal

    Local signals, systemic decline.

    Science (New York, N.Y.)·2026
    Same journal

    The mechanics of liver regeneration.

    Science (New York, N.Y.)·2026
    Same journal

    Computing in a memory with physics.

    Science (New York, N.Y.)·2026
    Same journal

    Retraction.

    Science (New York, N.Y.)·2026
    Same journal

    Making time.

    Science (New York, N.Y.)·2026
    See all related articles

    This study introduces a computer program for planning organic synthesis routes. It uses retrosynthetic analysis and a database to efficiently generate chemical pathways for complex molecules.

    Area of Science:

    • Organic Chemistry
    • Computational Chemistry
    • Chemical Synthesis

    Background:

    • Planning synthetic routes for complex organic molecules is a significant challenge in chemistry.
    • Traditional methods often rely on expert intuition and extensive literature searches.
    • Developing systematic strategies can improve the efficiency and success rate of organic synthesis.

    Purpose of the Study:

    • To describe an interactive computer program designed to aid in the planning of organic synthesis.
    • To present a computational approach for generating synthetic pathways for complex organic molecules.
    • To facilitate the exploration of alternative synthetic routes through automated analysis.

    Main Methods:

    • Utilizing general strategies of retrosynthetic analysis.

    Related Experiment Videos

  • Employing a database of chemical reactions and structures.
  • Implementing bidirectional search (retrosynthetic and synthetic).
  • Integrating computer graphics for user interaction and visualization.

    • Main Results:

    • The program generates pathways of chemical intermediates for a given target structure.
    • It provides a systematic and interactive approach to synthetic planning.
    • Facilitates the identification of multiple potential synthetic routes.

    Conclusions:

    • The developed interactive computer program effectively aids in planning complex organic syntheses.
    • Retrosynthetic analysis combined with a database offers a powerful tool for chemical synthesis pathway generation.
    • Computer-assisted methods enhance the efficiency and accessibility of designing synthetic routes.