Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RNA-sequencing of myxoinflammatory fibroblastic sarcomas reveals a novel SND1::BRAF fusion and 3 different molecular aberrations with the potential to upregulate the TEAD1 gene including SEC23IP::VGLL3 and TEAD1::MRTFB gene fusions.

Virchows Archiv : an international journal of pathology·2022
Same author

Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck.

Genes, chromosomes & cancer·2022
Same author

RREB1::MRTFB fusion-positive extra-glossal mesenchymal neoplasms: A series of five cases expanding their anatomic distribution and highlighting significant morphological and phenotypic diversity.

Genes, chromosomes & cancer·2022
Same author

Calcification in Salivary Gland Cancer Mimicking Sialolithiasis-A Diagnostic Pitfall on Imaging: Report of Two Cases and Brief Review of the Literature.

Journal of clinical medicine·2022
Same author

MDM2 is a useful diagnostic marker for nasopharyngeal carcinoma.

Pathology, research and practice·2022
Same author

Sinonasal mixed transitional epithelial-seromucinous papillary glandular neoplasms with BRAF p.V600E mutations - sinonasal analogues to the sialadenoma papilliferum family tumors.

Virchows Archiv : an international journal of pathology·2022
Same journal

Role of INSM1 expression in the diagnostic work-up of pancreatic acinar cell carcinoma with special reference to the differential diagnosis with neuroendocrine tumor.

Virchows Archiv : an international journal of pathology·2026
Same journal

Mismatch repair protein deficiency (MMRd) and high microsatellite instability (MSI-H) in gastrointestinal stromal tumour (GIST) - a case report and review of the literature of this exceedingly rare phenotype.

Virchows Archiv : an international journal of pathology·2026
Same journal

Primary renal synovial sarcoma: a clinicopathological study of 23 cases highlighting the diagnostic value of SS18-SSX, TLE1, and INI1 immunohistochemistry panel.

Virchows Archiv : an international journal of pathology·2026
Same journal

Clinicopathologic characteristics of uterine malignant epithelioid neoplasms with EWSR1::CREM fusion: Report of 2 cases at a novel site with literature review.

Virchows Archiv : an international journal of pathology·2026
Same journal

Gallbladder MiNEN arising in association with an intracholecystic papillary neoplasm exhibiting divergent p53 expression.

Virchows Archiv : an international journal of pathology·2026
Same journal

Penile squamous cell carcinomas with the usual-type morphology can be HPV-associated - Routine p16/HPV testing should be performed in all penile squamous cell carcinomas regardless of morphology.

Virchows Archiv : an international journal of pathology·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

5.8K

Update on olfactory neuroblastoma.

Fernando Lopez1, Abbas Agaimy2, Alessandro Franchi3

  • 1Department of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Avenida de Roma, S/N, 33011, Oviedo, Asturias, Spain. flopez_1981@yahoo.es.

Virchows Archiv : an International Journal of Pathology
|February 22, 2024
PubMed
Summary
This summary is machine-generated.

Olfactory neuroblastomas are rare nasal cavity cancers. Molecular markers and standardized treatments are crucial for accurate diagnosis, personalized therapy, and improved patient outcomes.

Keywords:
ChemotherapyDiagnosisEsthesioneuroblastomasMolecular characterisationOlfactory neuroblastomasOutcomesRadiotherapySinonasal tumoursStaging systemSurgery

More Related Videos

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

3.6K
Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
06:32

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

16.3K

Related Experiment Videos

Last Updated: Jul 2, 2025

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

5.8K
Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery
09:53

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

3.6K
Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells
06:32

Isolation, Enrichment, and Maintenance of Medulloblastoma Stem Cells

Published on: September 1, 2010

16.3K

Area of Science:

  • Oncology
  • Pathology
  • Molecular Biology

Background:

  • Olfactory neuroblastomas (ONBs) are rare malignancies originating from olfactory receptor cells in the nasal cavity.
  • Accurate diagnosis is challenging, particularly for poorly differentiated tumors, impacting clinical outcomes and treatment strategies.
  • Standardization of diagnosis, treatment, and outcome prediction remains difficult due to limited large-scale studies.

Purpose of the Study:

  • To review the current knowledge on the histopathological diagnosis of olfactory neuroblastomas.
  • To summarize the molecular biology of these tumors.
  • To outline the current management strategies and challenges in treating olfactory neuroblastomas.

Main Methods:

  • Literature review of histopathological diagnostic criteria for olfactory neuroblastomas.
  • Analysis of molecular and immunohistochemical markers relevant to ONB classification.
  • Synthesis of current treatment guidelines, including surgical and radiotherapeutic approaches.

Main Results:

  • Diagnostic challenges exist, especially with poorly differentiated tumors, highlighting the need for molecular and immunohistochemical markers.
  • Endoscopic surgical resection combined with postoperative irradiation is the primary treatment modality.
  • Elective neck irradiation is recommended to reduce the risk of nodal recurrence.

Conclusions:

  • Molecular characterization is essential for precise diagnosis and identifying therapeutic targets for personalized medicine.
  • Standardized diagnostic and treatment protocols are needed to improve patient outcomes for olfactory neuroblastomas.
  • Further research and large-scale studies are required to advance the management of this rare cancer.