Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

809
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
809
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

1.2K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.2K
Dialysis01:27

Dialysis

309
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
309
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

94
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
94
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

381
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
381
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

89
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
89

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A realist synthesis of integrated palliative care and oncology: Synopsis.

Health and social care delivery research·2026
Same author

Barriers and facilitators to exercise engagement during lung cancer treatment: a scoping review.

Cancer causes & control : CCC·2026
Same author

Improving the Understanding of Late Effects of Testicular Cancer in Adolescent and Young Adult Survivors: TRANSCEND-XR.

Andrology·2026
Same author

Using a generative co-design framework to adapt an exercise intervention as part of a multimodal intervention for patients' receiving haemodialysis with or at risk of renal cachexia.

Research involvement and engagement·2026
Same author

Multi-modal integrated intervention combining exercise, anti-inflammatory, and dietary advice (MMIEAD) for adults with kidney cachexia: protocol for a mixed-methods feasibility cluster randomised controlled trial and process evaluation.

Pilot and feasibility studies·2026
Same author

Design, adaptation and content validation of the Sheffield Profile for Assessment and Referral for Care in Colombian Spanish (SPARC-Sp-Col).

BMC palliative care·2026
Same journal

Seeing cachexia clearly: the evolution of body composition and radiological biomarkers in cancer wasting.

Current opinion in clinical nutrition and metabolic care·2026
Same journal

The updated recommendations for medical nutrition in the perioperative period: a focus on early oral intake.

Current opinion in clinical nutrition and metabolic care·2026
Same journal

Pediatric and adolescent nutritional and metabolic assessment in the precision era.

Current opinion in clinical nutrition and metabolic care·2026
Same journal

Nutrition in cirrhosis: bridging guidelines and practice in hepatic disease.

Current opinion in clinical nutrition and metabolic care·2026
Same journal

Metabolic health in a changing world: widening the lens to climate, cities, and place.

Current opinion in clinical nutrition and metabolic care·2026
Same journal

Beyond the scale: a systems-level reframing of obesity and metabolic care.

Current opinion in clinical nutrition and metabolic care·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2025

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

16.2K

Exercise and nutrition interventions for renal cachexia.

Adrian Slee1, Joanne Reid2

  • 1Division of Medicine, Faculty of Medical Sciences, University College London (UCL).

Current Opinion in Clinical Nutrition and Metabolic Care
|February 22, 2024
PubMed
Summary
This summary is machine-generated.

Exercise and nutrition interventions show promise for renal cachexia, improving strength and nutritional status. More research is needed on combined treatments for this condition.

More Related Videos

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

836
Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
07:44

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

1.1K

Related Experiment Videos

Last Updated: Jul 2, 2025

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

16.2K
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
06:28

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

Published on: April 28, 2023

836
Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass
07:44

Author Spotlight: Implementation of BIVA for Analyzing Disease Risk Factors in Patients with Low Body Cell Mass

Published on: July 14, 2023

1.1K

Area of Science:

  • Nephrology
  • Exercise Physiology
  • Nutritional Science

Background:

  • Renal cachexia is a serious condition in kidney disease patients, marked by weight loss, muscle wasting, and reduced quality of life.
  • Current evidence for multimodal exercise and nutrition interventions is limited but emerging.

Approach:

  • This review synthesizes current literature on exercise and nutrition strategies for managing renal cachexia.
  • Focuses on resistance training, aerobic training, oral nutritional supplementation, and omega-3 fatty acids.

Key Points:

  • Resistance training improves muscle strength and physical function, though effects on muscle mass are inconsistent.
  • Combined exercise (resistance and aerobic) may enhance functional capacity.
  • Oral nutritional supplementation and omega-3 fatty acids show potential benefits for nutritional status and anti-inflammatory effects.

Conclusions:

  • Individual exercise and nutrition interventions show benefits for renal cachexia.
  • Further research is urgently needed to develop and test specific multimodal treatment strategies.